MRI-guided prostate adaptive radiotherapy - A systematic review.
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Embargo End Date
ICR Authors
Authors
McPartlin, AJ
Li, XA
Kershaw, LE
Heide, U
Kerkmeijer, L
Lawton, C
Mahmood, U
Pos, F
van As, N
van Herk, M
Vesprini, D
van der Voort van Zyp, J
Tree, A
Choudhury, A
MR-Linac consortium,
Li, XA
Kershaw, LE
Heide, U
Kerkmeijer, L
Lawton, C
Mahmood, U
Pos, F
van As, N
van Herk, M
Vesprini, D
van der Voort van Zyp, J
Tree, A
Choudhury, A
MR-Linac consortium,
Document Type
Journal Article
Date
2016-06-01
Date Accepted
2016-04-09
Abstract
Dose escalated radiotherapy improves outcomes for men with prostate cancer. A plateau for benefit from dose escalation using EBRT may not have been reached for some patients with higher risk disease. The use of increasingly conformal techniques, such as step and shoot IMRT or more recently VMAT, has allowed treatment intensification to be achieved whilst minimising associated increases in toxicity to surrounding normal structures. To support further safe dose escalation, the uncertainties in the treatment target position will need be minimised using optimal planning and image-guided radiotherapy (IGRT). In particular the increasing usage of profoundly hypo-fractionated stereotactic therapy is predicated on the ability to confidently direct treatment precisely to the intended target for the duration of each treatment. This article reviews published studies on the influences of varies types of motion on daily prostate position and how these may be mitigated to improve IGRT in future. In particular the role that MRI has played in the generation of data is discussed and the potential role of the MR-Linac in next-generation IGRT is discussed.
Citation
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2016, 119 (3), pp. 371 - 380
Source Title
Publisher
ELSEVIER IRELAND LTD
ISSN
0167-8140
eISSN
1879-0887
Collections
Research Team
Stereotactic and Precision Body Radiotherapy