The Emerging Role of Local Therapy in Metastatic Prostate Cancer.
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Embargo End Date
ICR Authors
Authors
Sundahl, N
Tree, A
Parker, C
Tree, A
Parker, C
Document Type
Journal Article
Date
2020-01-20
Date Accepted
Abstract
PURPOSE OF REVIEW: This review summarizes the prospective clinical evidence regarding local therapy in metastatic prostate cancer. RECENT FINDINGS: The phase 3 STAMPEDE trial showed that prostate radiotherapy confers a survival benefit for newly diagnosed patients with low volume metastatic hormone-sensitive prostate cancer (HSPC). No survival benefit was noted for those with high volume disease. A subsequent meta-analysis combining the data of the STAMPEDE trial with that of the HORRAD trial corroborated these findings. The phase 2 randomized STOMP trial investigated local treatment of metastases in patients with oligometastatic HSPC, and showed an improvement in hormone therapy-free survival. Local prostate radiotherapy should be offered to patients with newly diagnosed low volume metastatic HSPC. Early clinical evidence suggests that local treatment to metastatic disease might be beneficial for patients with oligometastatic HSPC, but larger trials are awaited.
Citation
Current oncology reports, 2020, 22 (1), pp. 2 - ?
Source Title
Publisher
SPRINGER
ISSN
1523-3790
eISSN
1534-6269