Donated chemical probes for open science.
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Authors
Müller, S
Ackloo, S
Arrowsmith, CH
Bauser, M
Baryza, JL
Blagg, J
Böttcher, J
Bountra, C
Brown, PJ
Bunnage, ME
Carter, AJ
Damerell, D
Dötsch, V
Drewry, DH
Edwards, AM
Edwards, J
Elkins, JM
Fischer, C
Frye, SV
Gollner, A
Grimshaw, CE
IJzerman, A
Hanke, T
Hartung, IV
Hitchcock, S
Howe, T
Hughes, TV
Laufer, S
Li, VM
Liras, S
Marsden, BD
Matsui, H
Mathias, J
O'Hagan, RC
Owen, DR
Pande, V
Rauh, D
Rosenberg, SH
Roth, BL
Schneider, NS
Scholten, C
Singh Saikatendu, K
Simeonov, A
Takizawa, M
Tse, C
Thompson, PR
Treiber, DK
Viana, AY
Wells, CI
Willson, TM
Zuercher, WJ
Knapp, S
Mueller-Fahrnow, A
Ackloo, S
Arrowsmith, CH
Bauser, M
Baryza, JL
Blagg, J
Böttcher, J
Bountra, C
Brown, PJ
Bunnage, ME
Carter, AJ
Damerell, D
Dötsch, V
Drewry, DH
Edwards, AM
Edwards, J
Elkins, JM
Fischer, C
Frye, SV
Gollner, A
Grimshaw, CE
IJzerman, A
Hanke, T
Hartung, IV
Hitchcock, S
Howe, T
Hughes, TV
Laufer, S
Li, VM
Liras, S
Marsden, BD
Matsui, H
Mathias, J
O'Hagan, RC
Owen, DR
Pande, V
Rauh, D
Rosenberg, SH
Roth, BL
Schneider, NS
Scholten, C
Singh Saikatendu, K
Simeonov, A
Takizawa, M
Tse, C
Thompson, PR
Treiber, DK
Viana, AY
Wells, CI
Willson, TM
Zuercher, WJ
Knapp, S
Mueller-Fahrnow, A
Document Type
Journal Article
Date
2018-04-20
Date Accepted
2018-03-29
Abstract
Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been made available to academia. However, probe-associated data and control compounds, such as inactive structurally related molecules and their associated data, are generally not accessible. The lack of data and guidance makes it difficult for researchers to decide which chemical tools to choose. Several pharmaceutical companies (AbbVie, Bayer, Boehringer Ingelheim, Janssen, MSD, Pfizer, and Takeda) have therefore entered into a pre-competitive collaboration to make available a large number of innovative high-quality probes, including all probe-associated data, control compounds and recommendations on use (<ext-link ext-link-type="uri" xlink:href="https://openscienceprobes.sgc-frankfurt.de">https://openscienceprobes.sgc-frankfurt.de</ext-link><ext-link ext-link-type="uri" xlink:href="https://openscienceprobes.sgc-frankfurt.de/">/</ext-link>). Here we describe the chemical tools and target-related knowledge that have been made available, and encourage others to join the project.
Citation
eLife, 2018, 7
Source Title
Publisher
ISSN
2050-084X
eISSN
2050-084X
Collections
Research Team
Medicinal Chemistry 1