A Big Bang model of human colorectal tumor growth.
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ICR Authors
Authors
Sottoriva, A
Kang, H
Ma, Z
Graham, TA
Salomon, MP
Zhao, J
Marjoram, P
Siegmund, K
Press, MF
Shibata, D
Curtis, C
Kang, H
Ma, Z
Graham, TA
Salomon, MP
Zhao, J
Marjoram, P
Siegmund, K
Press, MF
Shibata, D
Curtis, C
Document Type
Journal Article
Date
2015-03-01
Date Accepted
2015-01-12
Abstract
What happens in early, still undetectable human malignancies is unknown because direct observations are impractical. Here we present and validate a 'Big Bang' model, whereby tumors grow predominantly as a single expansion producing numerous intermixed subclones that are not subject to stringent selection and where both public (clonal) and most detectable private (subclonal) alterations arise early during growth. Genomic profiling of 349 individual glands from 15 colorectal tumors showed an absence of selective sweeps, uniformly high intratumoral heterogeneity (ITH) and subclone mixing in distant regions, as postulated by our model. We also verified the prediction that most detectable ITH originates from early private alterations and not from later clonal expansions, thus exposing the profile of the primordial tumor. Moreover, some tumors appear 'born to be bad', with subclone mixing indicative of early malignant potential. This new model provides a quantitative framework to interpret tumor growth dynamics and the origins of ITH, with important clinical implications.
Citation
Nature genetics, 2015, 47 (3), pp. 209 - 216
DOI
Source Title
Publisher
NATURE PORTFOLIO
ISSN
1061-4036
eISSN
1546-1718