Night shift work and risk of breast cancer in women: the Generations Study cohort.
Loading...
Embargo End Date
ICR Authors
Authors
Jones, ME
Schoemaker, MJ
McFadden, EC
Wright, LB
Johns, LE
Swerdlow, AJ
Schoemaker, MJ
McFadden, EC
Wright, LB
Johns, LE
Swerdlow, AJ
Document Type
Journal Article
Date
2019-07-16
Date Accepted
2019-05-02
Abstract
BACKGROUND: It is plausible that night shift work could affect breast cancer risk, possibly by melatonin suppression or circadian clock disruption, but epidemiological evidence is inconclusive. METHODS: Using serial questionnaires from the Generations Study cohort, we estimated hazard ratios (HR) and 95% confidence intervals (95%CI) for breast cancer in relation to being a night shift worker within the last 10 years, adjusted for potential confounders. RESULTS: Among 102,869 women recruited in 2003-2014, median follow-up 9.5 years, 2059 developed invasive breast cancer. The HR in relation to night shift work was 1.00 (95%CI: 0.86-1.15). There was a significant trend with average hours of night work per week (P = 0.035), but no significantly raised risks for hours worked per night, nights worked per week, average hours worked per week, cumulative years of employment, cumulative hours, time since cessation, type of occupation, age starting night shift work, or age starting in relation to first pregnancy. CONCLUSIONS: The lack of overall association, and no association with all but one measure of dose, duration, and intensity in our data, does not support an increased risk of breast cancer from night shift work in women.
Citation
British journal of cancer, 2019, 121 (2), pp. 172 - 179
Source Title
Publisher
NATURE PUBLISHING GROUP
ISSN
0007-0920
eISSN
1532-1827
Research Team
Aetiological Epidemiology