Origins of STIL-TAL1 fusion genes in children who later developed paediatric T-cell acute lymphoblastic leukaemia: An investigation of neonatal blood spots.
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ICR Authors
Authors
Gustafsson, BM
Mattsson, K
Bogdanovic, G
Leijonhufvud, G
Honkaniemi, E
Ramme, K
Ford, AM
Mattsson, K
Bogdanovic, G
Leijonhufvud, G
Honkaniemi, E
Ramme, K
Ford, AM
Document Type
Journal Article
Date
2018-11-01
Date Accepted
2018-06-09
Date Available
Abstract
SCL/TAL1 interrupting locus (STIL)-T-cell acute leukaemia (TAL1) fusion genes are present in approximately 11-27% of children with paediatric T-cell acute lymphoblastic leukaemia (T-ALL), but the developmental timing of the rearrangement is still unknown. To investigate whether the fusion gene can be detected in neonatal blood spots (NBSs) from paediatric patients diagnosed with T-cell ALL, we analysed DNA from 38 paediatric patients with T-ALL by nested polymerase chain reaction and electrophoresis. The STIL-TAL1 fusion gene was not detected in NBSs from any of the 38 patients with T-ALL, suggesting that STIL-TAL1 fusion genes are most probably postnatal events in paediatric T-ALL.
Citation
Pediatric blood & cancer, 2018, 65 (11), pp. e27310 - ?
Rights
Source Title
Publisher
Wiley
ISSN
1545-5009
eISSN
1545-5017
Collections
Research Team
Biology of Childhood Leukaemia