IGF signalling in germ cells and testicular germ cell tumours: roles and therapeutic approaches.
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Embargo End Date
ICR Authors
Authors
Selfe, J
Shipley, JM
Shipley, JM
Document Type
Journal Article
Date
2019-07-01
Date Accepted
2019-05-05
Abstract
The insulin-like growth factor (IGF) axis plays key roles in normal tissue growth and development as well as in the progression of several tumour types and their subsequent growth and progression to a metastatic phenotype. This review explores the role of IGF system in normal germ cell development and function in addition to examining the evidence for deregulation of IGF signalling in cancer, with particular relevance to evidence supporting a role in testicular germ cell tumours (TGCTs). Despite the clear preclinical rationale for targeting the IGF axis in cancer, there has been a lack of progress in identifying which patients may benefit from such therapy. Future employment of agents targeting the IGF pathway is expected to concentrate on their use in combination with other treatments to prevent resistance and exploit their potential as chemo- and radiosensitizers.
Citation
Andrology, 2019, 7 (4), pp. 536 - 544
Source Title
Publisher
WILEY
ISSN
2047-2919
eISSN
2047-2927
Collections
Research Team
Sarcoma Molecular Pathology