Translational genomics of ovarian clear cell carcinoma.
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Authors
Khalique, S
Lord, CJ
Banerjee, S
Natrajan, R
Lord, CJ
Banerjee, S
Natrajan, R
Document Type
Journal Article
Date
2020-04-01
Date Accepted
2019-10-31
Abstract
Ovarian clear cell carcinomas (OCCC) are rare aggressive, chemo-resistant tumours comprising approximately 13% of all epithelial ovarian cancers, which have distinct clinical and molecular features, when compared to other gynaecological malignancies. At present, there are no specific licensed targeted therapies for OCCC, although a number of candidate targets have been identified. This review focuses on recent knowledge underpinning our understanding of the pathogenesis of OCCC including direct and synthetic-lethal therapeutic strategies in particular focussing on ARID1A deficiency. We also discuss current targeted clinical trials and immunotherapeutic approaches.
Citation
Seminars in cancer biology, 2020, 61 pp. 121 - 131
Source Title
Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
ISSN
1044-579X
eISSN
1096-3650
Collections
Research Team
Functional Genomics
Gene Function
Gene Function