Banana-shaped survival curves of metastatic renal cell carcinoma treated with first-line immune-combinations, not just a matter of "palateau".
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ICR Authors
Authors
Rebuzzi, SE
Fornarini, G
Signori, A
Rescigno, P
Banna, GL
Buti, S
Fornarini, G
Signori, A
Rescigno, P
Banna, GL
Buti, S
Document Type
Journal Article
Date
2024-12-31
Date Accepted
Abstract
The first-line therapy of metastatic renal cell carcinoma (mRCC) has revolutionized with the approval of immune checkpoint inhibitors (ICIs) in combination with or without tyrosine kinase inhibitors (TKIs). The choice among the many different immuno-combinations (ICI-ICI or ICI-TKI) is challenging due to the lack of predictive factors. The different shapes of the Kaplan-Meier survival curves (e.g. "banana-shaped curves") have raised many questions on the long-term survival benefit. Here, we analyzed the factors that could have impacted the different long-term survival, including the prognostic factors distribution (IMDC score), histological factors (sarcomatoid features, PD-L1 expression), and treatment characteristics (mechanism of action, duration, discontinuation rate). This overview highlights the factors that should be considered in the first-line setting for the patients' therapeutic choice and prognostic assessment. They are also fundamental parameters to examined for head-to-head studies and real-life, large-scale studies.
Citation
Human Vaccines and Immunotherapeutics, 2024, 20 (1), pp. 2351669 -
Source Title
Human Vaccines and Immunotherapeutics
Publisher
TAYLOR & FRANCIS INC
ISSN
2164-5515
eISSN
2164-554X
Collections
Research Team
PrCa Targeted Therapy