Are There Specific Cancer Stem Cell Markers?

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ICR Authors

Behrens, Axel

Authors

Lan, L
Behrens, A

Document Type

Journal Article

Date

2023-01-18

Date Accepted

2022-11-10

Abstract

The cancer stem cell (CSC) model states that heterogeneous tumor cell populations are organized in a hierarchical manner, with a small population of CSCs at the apex. These CSCs are capable of self-renewal and giving rise to other cancer cell populations, conceptually analogous to the function of normal adult stem cells present in almost all organs. However, there has been significant controversy regarding the existence and identification of CSCs. We argue that technical differences in experimentation and CSC assays, CSC niche-dependency and plasticity, and CSC heterogeneity itself may explain some of the differences observed.

Citation

Cancer Research, 2023, 83 (2), pp. 170 - 172

DOI

10.1158/0008-5472.CAN-22-2053

URI

https://repository.icr.ac.uk/handle/internal/5737

Rights

https://creativecommons.org/licenses/by-nc-nd/4.0/

Source Title

Cancer Research

Publisher

AMER ASSOC CANCER RESEARCH

ISSN

0008-5472

eISSN

1538-7445
1538-7445

Collections

Other ICR Research

Research Team

Convergence SC Management

Notes