The delineation of intraprostatic boost regions for radiotherapy using multimodality imaging.
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Embargo End Date
ICR Authors
Authors
Pathmanathan, AU
Alexander, EJ
Huddart, RA
Tree, AC
Alexander, EJ
Huddart, RA
Tree, AC
Document Type
Journal Article
Date
2016-11-01
Date Accepted
2016-05-01
Abstract
Dose escalation to the prostate improves tumor control but at the expense of increased rectal toxicity. Modern imaging can be used to detect the most common site of recurrence, the intraprostatic lesion (IPL), which has led to the concept of focusing dose escalation to the IPL in order to improve the therapeutic ratio. Imaging must be able to detect lesions with adequate sensitivity and specificity to accurately delineate the IPL. This information must be carefully integrated into the radiotherapy planning process to ensure the dose is targeted to the IPL. This review will consider the role and challenges of multiparametric MRI and PET computed tomography in delineating a tumor boost to be delivered by external beam radiotherapy.
Citation
Future oncology (London, England), 2016, 12 (21), pp. 2495 - 2511
Source Title
Publisher
FUTURE MEDICINE LTD
ISSN
1479-6694
eISSN
1744-8301
Collections
Research Team
Clinical Academic Radiotherapy (Huddart)