Autologous stem cell transplantation is safe and effective for fit older myeloma patients: exploratory results from the Myeloma XI trial.
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Embargo End Date
ICR Authors
Authors
Pawlyn, C
Cairns, D
Menzies, T
Jones, J
Jenner, M
Cook, G
Boyd, K
Drayson, M
Kaiser, M
Owen, R
Gregory, W
Morgan, G
Jackson, G
Davies, F
Cairns, D
Menzies, T
Jones, J
Jenner, M
Cook, G
Boyd, K
Drayson, M
Kaiser, M
Owen, R
Gregory, W
Morgan, G
Jackson, G
Davies, F
Document Type
Journal Article
Date
2022-01-01
Date Accepted
Abstract
Autologous stem cell transplant (ASCT) remains standard of care for consolidation after induction therapy for eligible newly diagnosed myeloma patients. In recent clinical trials comparing ASCT to delayed ASCT, patients aged over 65 were excluded. In real-world practice stem cell transplants are not restricted to those aged under 65 and clinicians decide on transplant eligibility based on patient fitness rather than a strict age cut off. Data from the UK NCRI Myeloma XI trial, a large phase III randomised controlled trial with pathways for transplant-eligible (TE) and ineligible (TNE) patients, was used in an exploratory analysis to examine the efficacy and toxicity of ASCT in older patients including analysis using an agematched population to compare outcomes for patients receiving similar induction therapy with or without ASCT. Older patients within the TE pathway were less likely to undergo stem cell harvest at the end of induction than younger patients and of those patients undergoing ASCT there was a reduction in PFS associated with increasing age. ASCT in older patients was well tolerated with no difference in morbidity or mortality between patients aged.
Citation
Haematologica, 2020, Online ahead of print pp. 0 - ?
Source Title
Publisher
FERRATA STORTI FOUNDATION
ISSN
0390-6078
eISSN
1592-8721
Collections
Research Team
Myeloma Biology and Therapeutics
Myeloma Group
Myeloma Group