Proteomic features of soft tissue tumours in adolescents and young adults.
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Embargo End Date
Authors
Tam, YB
Low, K
Ps, H
Chadha, M
Burns, J
Wilding, CP
Arthur, A
Chen, TW
Thway, K
Sadanandam, A
Jones, RL
Huang, PH
Low, K
Ps, H
Chadha, M
Burns, J
Wilding, CP
Arthur, A
Chen, TW
Thway, K
Sadanandam, A
Jones, RL
Huang, PH
Document Type
Journal Article
Date
2024-05-18
Date Accepted
2024-05-07
Abstract
BACKGROUND: Adolescents and young adult (AYA) patients with soft tissue tumours including sarcomas are an underserved group with disparities in treatment outcomes. METHODS: To define the molecular features between AYA and older adult (OA) patients, we analysed the proteomic profiles of a large cohort of soft tissue tumours across 10 histological subtypes (AYA n = 66, OA n = 243), and also analysed publicly available functional genomic data from soft tissue tumour cell lines (AYA n = 5, OA n = 8). RESULTS: Biological hallmarks analysis demonstrates that OA tumours are significantly enriched in MYC targets compared to AYA tumours. By comparing the patient-level proteomic data with functional genomic profiles from sarcoma cell lines, we show that the mRNA splicing pathway is an intrinsic vulnerability in cell lines from OA patients and that components of the spliceosome complex are independent prognostic factors for metastasis free survival in AYA patients. CONCLUSIONS: Our study highlights the importance of performing age-specific molecular profiling studies to identify risk stratification tools and targeted agents tailored for the clinical management of AYA patients.
Citation
Communications Medicine, 2024, 4 (1), pp. 93 -
Source Title
Communications Medicine
Publisher
SPRINGERNATURE
ISSN
2730-664X
eISSN
2730-664X
2730-664X
2730-664X
Collections
Research Team
Mol and Systems Oncology
Systems - Precision Med
Systems - Precision Med