Klotho: A Major Shareholder in Vascular Aging Enterprises.

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ICR Authors

Authors

Lim, K
Halim, A
Lu, T-S
Ashworth, A
Chong, I

Document Type

Journal Article

Date

2019-09-19

Date Accepted

2019-09-13

Date Available

Abstract

Accelerated vascular aging is a condition that occurs as a complication of several highly prevalent inflammatory conditions such as chronic kidney disease, cancer, HIV infection and diabetes. Age-associated vascular alterations underlie a continuum of expression toward clinically overt cardiovascular disease. This has contributed to the striking epidemiologic transition whereby such noncommunicable diseases have taken center stage as modern-day global epidemics and public health problems. The identification of α-Klotho, a remarkable protein that confers powerful anti-aging properties has stimulated significant interest. In fact, emerging data have provided fundamental rationale for Klotho-based therapeutic intervention for vascular diseases and multiple other potential indications. However, the application of such discoveries in Klotho research remains fragmented due to significant gaps in our molecular understanding of Klotho biology, as well as hurdles in clinical research and experimental barriers that must first be overcome. These advances will be critical to establish the scientific platform from which future Klotho-based interventional trials and therapeutic enterprises can be successfully launched.

Citation

International journal of molecular sciences, 2019, 20 (18)

Source Title

Publisher

MDPI

ISSN

1422-0067

eISSN

1422-0067

Research Team

Ashworth Collaborators

Notes