Cell Competition in Carcinogenesis.
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Embargo End Date
ICR Authors
Authors
Madan, E
Palma, AM
Vudatha, V
Trevino, JG
Natarajan, KN
Winn, RA
Won, KJ
Graham, TA
Drapkin, R
McDonald, SAC
Fisher, PB
Gogna, R
Palma, AM
Vudatha, V
Trevino, JG
Natarajan, KN
Winn, RA
Won, KJ
Graham, TA
Drapkin, R
McDonald, SAC
Fisher, PB
Gogna, R
Document Type
Journal Article
Date
2022-12-16
Date Accepted
2022-09-29
Abstract
The majority of human cancers evolve over time through the stepwise accumulation of somatic mutations followed by clonal selection akin to Darwinian evolution. However, the in-depth mechanisms that govern clonal dynamics and selection remain elusive, particularly during the earliest stages of tissue transformation. Cell competition (CC), often referred to as 'survival of the fittest' at the cellular level, results in the elimination of less fit cells by their more fit neighbors supporting optimal organism health and function. Alternatively, CC may allow an uncontrolled expansion of super-fit cancer cells to outcompete their less fit neighbors thereby fueling tumorigenesis. Recent research discussed herein highlights the various non-cell-autonomous principles, including interclonal competition and cancer microenvironment competition supporting the ability of a tumor to progress from the initial stages to tissue colonization. In addition, we extend current insights from CC-mediated clonal interactions and selection in normal tissues to better comprehend those factors that contribute to cancer development.
Citation
Cancer Research, 2022, pp. CAN-22-2217 -
Source Title
Cancer Research
Publisher
AMER ASSOC CANCER RESEARCH
ISSN
0008-5472
eISSN
1538-7445
1538-7445
1538-7445
Collections
Research Team
Genomics & evolut dynam