Immunological impact of cell death signaling driven by radiation on the tumor microenvironment.
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Embargo End Date
ICR Authors
Authors
Rodriguez-Ruiz, ME
Vitale, I
Harrington, KJ
Melero, I
Galluzzi, L
Vitale, I
Harrington, KJ
Melero, I
Galluzzi, L
Document Type
Journal Article
Date
2020-02-01
Date Accepted
2019-11-14
Abstract
Therapeutic irradiation of the tumor microenvironment causes differential activation of pro-survival and pro-death pathways in malignant, stromal, endothelial and immune cells, hence causing a profound cellular and biological reconfiguration via multiple, non-redundant mechanisms. Such mechanisms include the selective elimination of particularly radiosensitive cell types and consequent loss of specific cellular functions, the local release of cytokines and danger signals by dying radiosensitive cells, and altered cytokine secretion by surviving radioresistant cells. Altogether, these processes create chemotactic and immunomodulatory cues for incoming and resident immune cells. Here we discuss how cytoprotective and cytotoxic signaling modules activated by radiation in specific cell populations reshape the immunological tumor microenvironment.
Citation
Nature immunology, 2020, 21 (2), pp. 120 - 134
Source Title
Publisher
NATURE PORTFOLIO
ISSN
1529-2908
eISSN
1529-2916
Research Team
Targeted Therapy
Targeted Therapy
Targeted Therapy