Histone isoforms and the oncohistone code.
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Embargo End Date
ICR Authors
Authors
Flaus, A
Downs, JA
Owen-Hughes, T
Downs, JA
Owen-Hughes, T
Document Type
Journal Article
Date
2020-12-04
Date Accepted
2020-11-07
Abstract
Recent studies have highlighted the potential for missense mutations in histones to act as oncogenic drivers, leading to the term 'oncohistones'. While histone proteins are highly conserved, they are encoded by multigene families. There is heterogeneity among these genes at the level of the underlying sequence, the amino acid composition of the encoded histone isoform, and the expression levels. One question that arises, therefore, is whether all histone-encoding genes function equally as oncohistones. In this review, we consider this question and explore what this means in terms of the mechanisms by which oncohistones can exert their effects in chromatin.
Citation
Current opinion in genetics & development, 2020, 67 pp. 61 - 66
Source Title
Publisher
CURRENT BIOLOGY LTD
ISSN
0959-437X
eISSN
1879-0380
Collections
Research Team
Epigenetics and Genome Stability
Epigenetics and Genome Stability
Epigenetics and Genome Stability