Consensus guidelines for the definition, detection and interpretation of immunogenic cell death.

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e000337.full.pdf (1.59 MB)

Embargo End Date

ICR Authors

Harrington, Kevin
 Melcher, Alan

Authors

Galluzzi, L
Vitale, I
Warren, S
Adjemian, S
Agostinis, P
Martinez, AB
Chan, TA
Coukos, G
Demaria, S
Deutsch, E
Draganov, D
Edelson, RL
Formenti, SC
Fucikova, J
Gabriele, L
Gaipl, US
Gameiro, SR
Garg, AD
Golden, E
Han, J
Harrington, KJ
Hemminki, A
Hodge, JW
Hossain, DMS
Illidge, T
Karin, M
Kaufman, HL
Kepp, O
Kroemer, G
Lasarte, JJ
Loi, S
Lotze, MT
Manic, G
Merghoub, T
Melcher, AA
Mossman, KL
Prosper, F
Rekdal, Ø
Rescigno, M
Riganti, C
Sistigu, A
Smyth, MJ
Spisek, R
Stagg, J
Strauss, BE
Tang, D
Tatsuno, K
van Gool, SW
Vandenabeele, P
Yamazaki, T
Zamarin, D
Zitvogel, L
Cesano, A
Marincola, FM

Document Type

Journal Article

Date

2020-01-01

Date Accepted

2020-01-13

Abstract

Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic cell death (ICD), discuss the key factors that dictate the ability of dying cells to drive an adaptive immune response, summarize experimental assays that are currently available for the assessment of ICD in vitro and in vivo, and formulate guidelines for their interpretation.

Citation

Journal for immunotherapy of cancer, 2020, 8 (1)

DOI

10.1136/jitc-2019-000337

URI

https://repository.icr.ac.uk/handle/internal/3996

Rights

https://creativecommons.org/licenses/by/4.0

Source Title

Publisher

BMJ PUBLISHING GROUP

ISSN

2051-1426

eISSN

2051-1426

Collections

Radiotherapy and Imaging

Research Team

Translational Immunotherapy

Notes