Microglia and Other Cellular Mediators of Immunological Dysfunction in Schizophrenia: A Narrative Synthesis of Clinical Findings.

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ICR Authors

Magnani, Luca

Authors

Nguyen, KD
Amerio, A
Aguglia, A
Magnani, L
Parise, A
Conio, B
Serafini, G
Amore, M
Costanza, A

Document Type

Journal Article

Date

2023-08-19

Date Accepted

2023-08-17

Abstract

Schizophrenia is a complex psychiatric condition that may involve immune system dysregulation. Since most putative disease mechanisms in schizophrenia have been derived from genetic association studies and fluid-based molecular analyses, this review aims to summarize the emerging evidence on clinical correlates to immune system dysfunction in this psychiatric disorder. We conclude this review by attempting to develop a unifying hypothesis regarding the relative contributions of microglia and various immune cell populations to the development of schizophrenia. This may provide important translational insights that can become useful for addressing the multifaceted clinical presentation of schizophrenia.

Citation

Cells, 2023, 12 (16), pp. 2099 -

DOI

10.3390/cells12162099
10.3390/cells12162099

URI

https://repository.icr.ac.uk/handle/internal/6053

Rights

http://creativecommons.org/licenses/by/4.0/

Source Title

Cells

Publisher

MDPI

ISSN

2073-4409

eISSN

2073-4409
2073-4409

Collections

Breast Cancer Research

Research Team

Breast Epige Plast & Evol

Notes