A molecular quantitative trait locus map for osteoarthritis.
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ICR Authors
Authors
Steinberg, J
Southam, L
Roumeliotis, TI
Clark, MJ
Jayasuriya, RL
Swift, D
Shah, KM
Butterfield, NC
Brooks, RA
McCaskie, AW
Bassett, JHD
Williams, GR
Choudhary, JS
Wilkinson, JM
Zeggini, E
Southam, L
Roumeliotis, TI
Clark, MJ
Jayasuriya, RL
Swift, D
Shah, KM
Butterfield, NC
Brooks, RA
McCaskie, AW
Bassett, JHD
Williams, GR
Choudhary, JS
Wilkinson, JM
Zeggini, E
Document Type
Journal Article
Date
2021-02-26
Date Accepted
2021-02-03
Abstract
Osteoarthritis causes pain and functional disability for over 500 million people worldwide. To develop disease-stratifying tools and modifying therapies, we need a better understanding of the molecular basis of the disease in relevant tissue and cell types. Here, we study primary cartilage and synovium from 115 patients with osteoarthritis to construct a deep molecular signature map of the disease. By integrating genetics with transcriptomics and proteomics, we discover molecular trait loci in each tissue type and omics level, identify likely effector genes for osteoarthritis-associated genetic signals and highlight high-value targets for drug development and repurposing. These findings provide insights into disease aetiopathology, and offer translational opportunities in response to the global clinical challenge of osteoarthritis.
Citation
Nature communications, 2021, 12 (1), pp. 1309 - ?
Source Title
Publisher
NATURE PORTFOLIO
ISSN
2041-1723
eISSN
2041-1723