VICTOR: Vinflunine in advanced metastatic transitional cell carcinoma of the urothelium: A retrospective analysis of the use of vinflunine in multi-centre real life setting as second line chemotherapy through Free of Charge Programme for patients in the UK and Ireland.
Loading...
Embargo End Date
ICR Authors
Authors
Hussain, SA
Ansari, J
Huddart, R
Power, DG
Lyons, J
Wylie, J
Vilarino-Varlela, M
Elander, NO
McMenemin, R
Pickering, LM
Faust, G
Chauhan, S
Jackson, RJ
Ansari, J
Huddart, R
Power, DG
Lyons, J
Wylie, J
Vilarino-Varlela, M
Elander, NO
McMenemin, R
Pickering, LM
Faust, G
Chauhan, S
Jackson, RJ
Document Type
Journal Article
Date
2015-03-01
Date Accepted
2016-11-14
Abstract
There is no standard of care in the UK or Ireland for second-line chemotherapy for patients with advanced transitional cell carcinoma (TCCU). Vinflunine is approved for TCCU patients who have failed a platinum-based regimen, and is standard of care in Europe but is not routinely available in the UK. Data were collected retrospectively on patients who received vinfluine as a second-line treatment. The aims were to document the toxicity and efficacy in a real life setting. Data were collected on 49 patients from 9 sites across the UK and Ireland [median age, 64 (IQR, 57-70) years, 33 males]. All patients had advanced metastatic TCCU. Thirteen patients had bone or liver metastases, 4 patients had PS 2 and 11 patients had HB <10. Median vinflunine administration was 3.5 cycles (range 1-18). Most common grade 3-4 toxicities were constipation (4 patients) and fatigue (3 patients). Partial response rate was 29% (14 PR, 11 SD, 19 PD, 4 NE, 1 not available). Median OS was 9.1 (6.0, 12.7) months. Results are consistent with real life data from Europe. Toxicity is further reduced with prophylactic laxative and oral antibiotics. Vinflunine is an efficient and tolerable second line treatment in advanced TCCU.
Citation
International journal of oncology, 2017, 50 (3), pp. 768 - 772
Source Title
Publisher
AMER SOC CLINICAL ONCOLOGY
ISSN
1019-6439
eISSN
1791-2423
Collections
Research Team
Clinical Academic Radiotherapy (Huddart)