TGFΒ-induced transcription in cancer.
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Embargo End Date
ICR Authors
Authors
Cantelli, G
Crosas-Molist, E
Georgouli, M
Sanz-Moreno, V
Crosas-Molist, E
Georgouli, M
Sanz-Moreno, V
Document Type
Journal Article
Date
2017-02-01
Date Accepted
2016-08-19
Abstract
The Transforming Growth Factor-beta (TGFβ) pathway mediates a broad spectrum of cellular processes and is involved in several diseases, including cancer. TGFβ has a dual role in tumours, acting as a tumour suppressor in the early phase of tumorigenesis and as a tumour promoter in more advanced stages. In this review, we discuss the effects of TGFβ-driven transcription on all stages of tumour progression, with special focus on lung cancer. Since some TGFβ target genes are specifically involved in promoting metastasis, we speculate that these genes might be good targets to block tumour progression without compromising the tumour suppressor effects of the TGFβ pathway.
Citation
Seminars in Cancer Biology, 2017, 42 pp. 60 - 69
Source Title
Seminars in Cancer Biology
Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
ISSN
1044-579X
eISSN
1096-3650