Unconventional role of RAC1 in MET-driven anchorage-independent tumor growth.
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Embargo End Date
ICR Authors
Authors
Hervieu, A
Kermorgant, S
Kermorgant, S
Document Type
Journal Article
Date
2020-08-18
Date Accepted
Abstract
We reported that RAC1 is a master regulator of cell migration and anchorage-independent growth, downstream of the oncogenic Receptor Tyrosine Kinase (RTK) MET. RAC1 growth-promoting role is guanosine triphosphatase (GTPase)- and phosphatidylinositol 3-kinase (PI3K)-independent but promotes mammalian target of rapamycin (mTOR) signaling through triggering its plasma membrane localization.
Citation
Molecular & cellular oncology, 2020, 7 (6), pp. 1803029 - ?
Source Title
Publisher
TAYLOR & FRANCIS INC
ISSN
2372-3556
eISSN
2372-3556
Collections
Research Team
Signal Transduction & Molecular Pharmacology