Health-related quality of life around the time of diagnosis in patients with bladder cancer.
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Embargo End Date
ICR Authors
Authors
Yu, EY-W
Nekeman, D
Billingham, LJ
James, ND
Cheng, KK
Bryan, RT
Wesselius, A
Zeegers, MP
Nekeman, D
Billingham, LJ
James, ND
Cheng, KK
Bryan, RT
Wesselius, A
Zeegers, MP
Document Type
Journal Article
Date
2019-12-01
Date Accepted
Abstract
OBJECTIVES: To quantify the health-related quality of life (HRQoL) of patients with bladder cancer around the time of diagnosis and to test the hypotheses of a two-factor model for the HRQoL questionnaire QLQ-C30. METHODS: From participants in the Bladder Cancer Prognoses Programme, a multicentre cohort study, sociodemographic data were collected using semi-structured face-to-face interviews. Answers to the QLQ-C30 were transformed into a scale from 0 to 100. HRQoL data were analysed in multivariate analyses. The hypothesized two-factor (Physical and Mental Health) domain structure of the QLQ-C30 was also tested with confirmatory factor analyses (CFA). RESULTS: A total of 1160 participants (78%) completed the questionnaire after initial visual diagnosis and before pathological confirmation. Despite non-muscle-invasive bladder cancer (NMIBC) being associated with a higher HRQoL than carcinoma invading bladder muscle, only the domain Role Functioning was clinically significantly better in patients with NMIBC. Age, gender, bladder cancer stage and comorbidity all had a significant influence on QLQ-C30 scores. The CFA showed an overall good fit of the hypothesized two-factor model. CONCLUSION: This study identified a baseline reference value for HRQoL for patients with bladder cancer, which allows better evaluation of any changes in HRQoL as disease progresses or after treatment. In addition, a two-factor (Physical and Mental Health) model was developed for the QLQ-C30.
Citation
BJU international, 2019, 124 (6), pp. 984 - 991
Source Title
Publisher
WILEY
ISSN
1464-4096
eISSN
1464-410X
Collections
Research Team
Prostate and Bladder Cancer Research