Cisplatin Substitution with Carboplatin During Radical Chemoradiotherapy for Oesophagogastric Carcinoma: Outcomes from a Tertiary Centre.
Loading...
Embargo End Date
ICR Authors
Authors
Athauda, A
Watkins, D
Mohammed, K
Chau, I
Starling, N
Rao, S
Tait, D
Aitken, K
Cunningham, D
Watkins, D
Mohammed, K
Chau, I
Starling, N
Rao, S
Tait, D
Aitken, K
Cunningham, D
Document Type
Journal Article
Date
2018-10
Date Accepted
2018-09-04
Abstract
Background/aim Cisplatin-based radical chemoradiotherapy (CRT) is utilised in oesophagogastric (OG) cancer but the toxicity profile of cisplatin limits its use. This study aimed to evaluate the clinical characteristics and outcomes of patients treated with either cisplatin or carboplatin based CRT at our institution.Materials and methods This is a retrospective analysis of patients with localised OG cancer undergoing CRT with cisplatin/fluoropyrimidine (CX/F) or carboplatin/fluoropyrimidine (CarboX/F) between January 2001 and December 2014.Results A total of 91 eligible patients were included. Median age was 65 years (IQR=57-75) for CX/F and 77 years (IQR=69-80) for CarboX/F. Adenocarcinoma histology and Charlson comorbidity index were higher in the CarboX/F group. Endoscopic complete response (CR) was achieved in 64% of CX/F group and 48% of CarboX/F group (p=0.19). The median PFS for CX/F was 31.0 months (95%CI=18.2-NE) vs. 18.7 months for CarboX/F (95%CI=13.5-30.4; HR=1.49, p=0.21).Conclusion Despite significant differences in baseline clinical characteristics, patients treated with carboplatin CRT demonstrated no significant difference in PFS or endoscopic CR rate, compared to those treated with cisplatin.
Citation
Anticancer research, 2018, 38 (10), pp. 5943 - 5949
Source Title
Publisher
ISSN
0250-7005
eISSN
1791-7530
Collections
Research Team
Gastrointestinal Cancers Clinical Trials
Medicine (RMH Smith Cunningham)
Medicine (RMH Smith Cunningham)