Practical recommendations for radium-223 treatment of metastatic castration-resistant prostate cancer.
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Embargo End Date
ICR Authors
Authors
Du, Y
Carrio, I
De Vincentis, G
Fanti, S
Ilhan, H
Mommsen, C
Nitzsche, E
Sundram, F
Vogel, W
Oyen, W
Lewington, V
Carrio, I
De Vincentis, G
Fanti, S
Ilhan, H
Mommsen, C
Nitzsche, E
Sundram, F
Vogel, W
Oyen, W
Lewington, V
Document Type
Journal Article
Date
2017-09
Date Accepted
2017-06-07
Abstract
Purpose Radium Ra 223 dichloride (radium-223, Xofigo®) is the first targeted alpha therapy for patients with castration-resistant prostate cancer and symptomatic bone metastases. Radium-223 provides a new treatment option for this setting, but also necessitates a new treatment management approach. We provide straightforward and practical recommendations for European nuclear medicine centres to optimize radium-223 service provision.Methods An independent research consultancy agency observed radium-223 procedures and conducted interviews with all key staff members involved in radium-223 treatment delivery in 11 nuclear medicine centres across six countries (Germany, Italy, the Netherlands, Spain, Switzerland and the UK) experienced in administering radium-223. The findings were collated and discussed at a meeting of experts from these centres, during which key consensus recommendations were defined.Results The recommendations cover centre organization and preparation; patient referral; radium-223 ordering, preparation and disposal; radium-223 treatment delivery/administration; and patient experience. Guidance includes structured coordination and communication within centres and multidisciplinary teams, focusing on sharing best practice to provide high-quality, patient-centred care throughout the treatment pathway.Conclusions These expert recommendations are intended to complement existing management guidelines. Sharing best practice and experience will help nuclear medicine centres to optimize radium-223 service provision and improve patient care.
Citation
European journal of nuclear medicine and molecular imaging, 2017, 44 (10), pp. 1671 - 1678
Source Title
Publisher
ISSN
1619-7070
eISSN
1619-7089
Collections
Research Team
Translational Molecular Imaging