Circulating cell-free DNA: Translating prostate cancer genomics into clinical care.
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Embargo End Date
ICR Authors
Authors
Gasi Tandefelt, D
de Bono, J
de Bono, J
Document Type
Journal Article
Date
2020-04-01
Date Accepted
2019-12-13
Abstract
Only in the past decade tremendous advances have been made in understanding prostate cancer genomics and consequently in applying new treatment strategies. As options regarding treatments are increasing so are the challenges in selecting the right treatment option for each patient and not the least, understanding the optimal time-point and sequence of applying available treatments. Critically, without reliable methods that enable sequential monitoring of evolving genotypes in individual patients, we will never reach effective personalised driven treatment approaches. This review focuses on the clinical implications of prostate cancer genomics and the potential of cfDNA in facilitating treatment management.
Citation
Molecular aspects of medicine, 2020, 72 pp. 100837 - ?
Source Title
Publisher
ELSEVIER
ISSN
0098-2997
eISSN
1872-9452
Collections
Research Team
Prostate Cancer Targeted Therapy Group