Adamts18 deletion results in distinct developmental defects and provides a model for congenital disorders of lens, lung, and female reproductive tract development.
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Embargo End Date
ICR Authors
Authors
Ataca, D
Caikovski, M
Piersigilli, A
Moulin, A
Benarafa, C
Earp, SE
Guri, Y
Kostic, C
Arsenijevic, Y
Soininen, R
Apte, SS
Brisken, C
Caikovski, M
Piersigilli, A
Moulin, A
Benarafa, C
Earp, SE
Guri, Y
Kostic, C
Arsenijevic, Y
Soininen, R
Apte, SS
Brisken, C
Document Type
Journal Article
Date
2016-11-15
Date Accepted
Abstract
The ADAMTS family comprises 19 secreted metalloproteinases that cleave extracellular matrix components and have diverse functions in numerous disease and physiological contexts. A number of them remain 'orphan' proteases and among them is ADAMTS18, which has been implicated in developmental eye disorders, platelet function and various malignancies. To assess in vivo function of ADAMTS18, we generated a mouse strain with inactivated Adamts18 alleles. In the C57Bl6/Ola background, Adamts18-deficient mice are born in a normal Mendelian ratio, and are viable but show a transient growth delay. Histological examination revealed a 100% penetrant eye defect resulting from leakage of lens material through the lens capsule occurring at embryonic day (E)13.5, when the lens grows rapidly. Adamts18-deficient lungs showed altered bronchiolar branching. Fifty percent of mutant females are infertile because of vaginal obstruction due to either a dorsoventral vaginal septum or imperforate vagina. The incidence of ovarian rete is increased in the mutant mouse strain. Thus, Adamts18 is essential in the development of distinct tissues and the new mouse strain is likely to be useful for investigating ADAMTS18 function in human disease, particularly in the contexts of infertility and carcinogenesis.
Citation
Biology open, 2016, 5 (11), pp. 1585 - 1594
Source Title
Publisher
COMPANY OF BIOLOGISTS LTD
ISSN
2046-6390
eISSN
2046-6390
Collections
Research Team
Endocrine control mechanisms