Isolated limb perfusion for unresectable extremity cutaneous squamous cell carcinoma; an effective limb saving strategy.
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Embargo End Date
ICR Authors
Authors
Huis In 't Veld, EA
Grünhagen, DJ
Deroose, JP
Nijsten, TEC
Wouters, MWJM
Verhoef, C
van Houdt, WJ
Hayes, AJ
Grünhagen, DJ
Deroose, JP
Nijsten, TEC
Wouters, MWJM
Verhoef, C
van Houdt, WJ
Hayes, AJ
Document Type
Journal Article
Date
2018-08-14
Date Accepted
2018-05-22
Abstract
BACKGROUND: A small minority of patients present with locally advanced cutaneous Squamous Cell Carcinoma (cSCC). The aim of this study was to evaluate the effectiveness of Tumour necrosis factor α (TNF) and melphalan based isolated limb perfusion (TM-ILP) as a limb saving strategy for locally advanced extremity cSCC. METHODS: A retrospective search from prospectively maintained databases, at two tertiary referral centers, was performed to identify patients treated with TM-ILP for locally advanced cSSC of an extremity between 2000 and 2015. RESULTS: A total of 30 patients treated with TM-ILP for cSCC were identified, with a median age of 71 years (36-92) and 50% female. Response could not be evaluated in 3 patients. After a median follow up of 25 months, the overall response rate was 81% (n = 22), with 16 patients having a complete response (CR, 59%). A total of 7 patients developed local recurrence, with a median time to recurrence of 9 months (Interquartile Range 7-10). Progressive disease was observed in 5 patients (19%). Limb salvage rate was 80%. The overall 2-year survival was 67%. CONCLUSIONS: TM-ILP should be considered as an option in patients with locally advanced cSCC in specialised centers, resulting in a high limb salvage rate.
Citation
British journal of cancer, 2018, 119 (4), pp. 429 - 434
Source Title
Publisher
NATURE PUBLISHING GROUP
ISSN
0007-0920
eISSN
1532-1827
Collections
Research Team
Sarcoma and Melanoma Surgery