Genomic landscape of diffuse glioma revealed by whole genome sequencing.
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Authors
Kinnersley, B
Jung, J
Cornish, AJ
Chubb, D
Laxton, R
Frangou, A
Gruber, AJ
Sud, A
Caravagna, G
Sottoriva, A
Wedge, DC
Booth, T
Al-Sarraj, S
Lawrence, SED
Albanese, E
Anichini, G
Baxter, D
Boukas, A
Chowdhury, YA
D'Urso, P
Corns, R
Dapaah, A
Edlmann, E
Greenway, F
Grundy, P
Hill, CS
Jenkinson, MD
Trichinopoly Krishna, S
Smith, S
Manivannan, S
Martin, AJ
Matloob, S
Mukherjee, S
O'Neill, K
Plaha, P
Pollock, J
Price, S
Rominiyi, O
Sachdev, B
Saeed, F
Sinha, S
Thorne, L
Ughratdar, I
Whitfield, P
Youshani, AS
Bulbeck, H
Arumugam, P
Houlston, R
Ashkan, K
Jung, J
Cornish, AJ
Chubb, D
Laxton, R
Frangou, A
Gruber, AJ
Sud, A
Caravagna, G
Sottoriva, A
Wedge, DC
Booth, T
Al-Sarraj, S
Lawrence, SED
Albanese, E
Anichini, G
Baxter, D
Boukas, A
Chowdhury, YA
D'Urso, P
Corns, R
Dapaah, A
Edlmann, E
Greenway, F
Grundy, P
Hill, CS
Jenkinson, MD
Trichinopoly Krishna, S
Smith, S
Manivannan, S
Martin, AJ
Matloob, S
Mukherjee, S
O'Neill, K
Plaha, P
Pollock, J
Price, S
Rominiyi, O
Sachdev, B
Saeed, F
Sinha, S
Thorne, L
Ughratdar, I
Whitfield, P
Youshani, AS
Bulbeck, H
Arumugam, P
Houlston, R
Ashkan, K
Document Type
Journal Article
Date
2025-05-07
Date Accepted
2025-04-11
Abstract
Diffuse gliomas are the commonest malignant primary brain tumour in adults. Herein, we present analysis of the genomic landscape of adult glioma, by whole genome sequencing of 403 tumours (256 glioblastoma, 89 astrocytoma, 58 oligodendroglioma; 338 primary, 65 recurrence). We identify an extended catalogue of recurrent coding and non-coding genetic mutations that represents a source for future studies and provides a high-resolution map of structural variants, copy number changes and global genome features including telomere length, mutational signatures and extrachromosomal DNA. Finally, we relate these to clinical outcome. As well as identifying drug targets for treatment of glioma our findings offer the prospect of improving treatment allocation with established targeted therapies.
Citation
Nature Communications, 2025, 16 (1), pp. 4233 -
Source Title
Nature Communications
Publisher
NATURE PORTFOLIO
ISSN
2041-1723
eISSN
2041-1723
Collections
Research Team
Cancer Genomics