DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation.
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ICR Authors
Authors
Quaglia, F
Mészáros, B
Salladini, E
Hatos, A
Pancsa, R
Chemes, LB
Pajkos, M
Lazar, T
Peña-Díaz, S
Santos, J
Ács, V
Farahi, N
Fichó, E
Aspromonte, MC
Bassot, C
Chasapi, A
Davey, NE
Davidović, R
Dobson, L
Elofsson, A
Erdős, G
Gaudet, P
Giglio, M
Glavina, J
Iserte, J
Iglesias, V
Kálmán, Z
Lambrughi, M
Leonardi, E
Longhi, S
Macedo-Ribeiro, S
Maiani, E
Marchetti, J
Marino-Buslje, C
Mészáros, A
Monzon, AM
Minervini, G
Nadendla, S
Nilsson, JF
Novotný, M
Ouzounis, CA
Palopoli, N
Papaleo, E
Pereira, PJB
Pozzati, G
Promponas, VJ
Pujols, J
Rocha, ACS
Salas, M
Sawicki, LR
Schad, E
Shenoy, A
Szaniszló, T
Tsirigos, KD
Veljkovic, N
Parisi, G
Ventura, S
Dosztányi, Z
Tompa, P
Tosatto, SCE
Piovesan, D
Mészáros, B
Salladini, E
Hatos, A
Pancsa, R
Chemes, LB
Pajkos, M
Lazar, T
Peña-Díaz, S
Santos, J
Ács, V
Farahi, N
Fichó, E
Aspromonte, MC
Bassot, C
Chasapi, A
Davey, NE
Davidović, R
Dobson, L
Elofsson, A
Erdős, G
Gaudet, P
Giglio, M
Glavina, J
Iserte, J
Iglesias, V
Kálmán, Z
Lambrughi, M
Leonardi, E
Longhi, S
Macedo-Ribeiro, S
Maiani, E
Marchetti, J
Marino-Buslje, C
Mészáros, A
Monzon, AM
Minervini, G
Nadendla, S
Nilsson, JF
Novotný, M
Ouzounis, CA
Palopoli, N
Papaleo, E
Pereira, PJB
Pozzati, G
Promponas, VJ
Pujols, J
Rocha, ACS
Salas, M
Sawicki, LR
Schad, E
Shenoy, A
Szaniszló, T
Tsirigos, KD
Veljkovic, N
Parisi, G
Ventura, S
Dosztányi, Z
Tompa, P
Tosatto, SCE
Piovesan, D
Document Type
Journal Article
Date
2022-01-07
Date Accepted
2021-10-20
Abstract
The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report here recent updates of DisProt version 9, including a restyled web interface, refactored Intrinsically Disordered Proteins Ontology (IDPO), improvements in the curation process and significant content growth of around 30%. Higher quality and consistency of annotations is provided by a newly implemented reviewing process and training of curators. The increased curation capacity is fostered by the integration of DisProt with APICURON, a dedicated resource for the proper attribution and recognition of biocuration efforts. Better interoperability is provided through the adoption of the Minimum Information About Disorder (MIADE) standard, an active collaboration with the Gene Ontology (GO) and Evidence and Conclusion Ontology (ECO) consortia and the support of the ELIXIR infrastructure.
Citation
Nucleic acids research, 2022, 50 (D1), pp. D480 - D487
Source Title
Publisher
OXFORD UNIV PRESS
ISSN
0305-1048
eISSN
1362-4962
1362-4962
1362-4962