Descriptive analysis of MRI functional changes occurring during reduced dose radiotherapy for myxoid liposarcomas.
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Embargo End Date
ICR Authors
Authors
Kousi, E
Messiou, C
Miah, A
Orton, M
Haas, R
Thway, K
Hopkinson, G
Zaidi, S
Smith, M
Barquin, E
Moskovic, E
Fotiadis, N
Strauss, D
Hayes, A
Schmidt, MA
Messiou, C
Miah, A
Orton, M
Haas, R
Thway, K
Hopkinson, G
Zaidi, S
Smith, M
Barquin, E
Moskovic, E
Fotiadis, N
Strauss, D
Hayes, A
Schmidt, MA
Document Type
Journal Article
Date
2021-10-01
Date Accepted
2021-09-21
Abstract
OBJECTIVES: Myxoid liposarcomas (MLS) show enhanced response to radiotherapy due to their distinctive vascular pattern and therefore could be effectively treated with lower radiation doses. This is a descriptive study to explore the use of functional MRI to identify response in a uniform cohort of MLS patients treated with reduced dose radiotherapy. METHODS: 10 patients with MLS were imaged pre-, during, and post-radiotherapy receiving reduced dose radiotherapy and the response to treatment was histopathologically assessed post-radiotherapy. Apparent diffusion coefficient (ADC), T2* relaxation time, volume transfer constant (Ktrans), initial area under the gadolinium curve over 60 s (IAUGC60) and (Gd) were estimated for a central tumour volume. RESULTS: All parameters showed large inter- and intrasubject variabilities. Pre-treatment (Gd), IAUGC60 and Ktrans were significantly different between responders and non-responders. Post-radiotherapy reductions from baseline were demonstrated for T2*, (Gd), IAUGC60 and Ktrans for responders. No statistically significant ADC differences were demonstrated between the two response groups. Significantly greater early tumour volume reductions were observed for responders. CONCLUSIONS: MLS are heterogenous lesions, characterised by a slow gradual contrast-agent uptake. Pre-treatment vascular parameters, early changes to tumour volume, vascular parameters and T2* have potential in identifying response to treatment. The delayed (Gd) is a suitable descriptive parameter, relying simply on T1 measurements. Volume changes precede changes in MLS functionality and could be used to identify early response. ADVANCES IN KNOWLEDGE: MLS are are characterised by slow gradual contrast-agent uptake. Measurement of the delayed contrast-agent uptake (Gd) is simple to implement and able to discriminate response.
Citation
British Journal of Radiology, 2021, 94 (1126), pp. 20210310 -
Source Title
British Journal of Radiology
Publisher
OXFORD UNIV PRESS
ISSN
0007-1285
eISSN
1748-880X
1748-880X
1748-880X
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Research Team
Translational Sarcoma, Melanoma and Rare Tumour Surgery
Sarcoma&Melanoma Surgery
Sarcoma&Melanoma Surgery