Genome-wide association studies of cancer: current insights and future perspectives.
Loading...
Embargo End Date
ICR Authors
Authors
Sud, A
Kinnersley, B
Houlston, RS
Kinnersley, B
Houlston, RS
Document Type
Journal Article
Date
2017-11-01
Date Accepted
2017-08-07
Abstract
Genome-wide association studies (GWAS) provide an agnostic approach for investigating the genetic basis of complex diseases. In oncology, GWAS of nearly all common malignancies have been performed, and over 450 genetic variants associated with increased risks have been identified. As well as revealing novel pathways important in carcinogenesis, these studies have shown that common genetic variation contributes substantially to the heritable risk of many common cancers. The clinical application of GWAS is starting to provide opportunities for drug discovery and repositioning as well as for cancer prevention. However, deciphering the functional and biological basis of associations is challenging and is in part a barrier to fully unlocking the potential of GWAS.
Citation
Nature reviews. Cancer, 2017, 17 (11), pp. 692 - 704
Source Title
Publisher
NATURE PORTFOLIO
ISSN
1474-175X
eISSN
1474-1768
Collections
Research Team
Cancer Genomics