Two Novel Susceptibility Loci for Prostate Cancer in Men of African Ancestry.
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ICR Authors
Authors
Conti, DV
Wang, K
Sheng, X
Bensen, JT
Hazelett, DJ
Cook, MB
Ingles, SA
Kittles, RA
Strom, SS
Rybicki, BA
Nemesure, B
Isaacs, WB
Stanford, JL
Zheng, W
Sanderson, M
John, EM
Park, JY
Xu, J
Stevens, VL
Berndt, SI
Huff, CD
Wang, Z
Yeboah, ED
Tettey, Y
Biritwum, RB
Adjei, AA
Tay, E
Truelove, A
Niwa, S
Sellers, TA
Yamoah, K
Murphy, AB
Crawford, DC
Gapstur, SM
Bush, WS
Aldrich, MC
Cussenot, O
Petrovics, G
Cullen, J
Neslund-Dudas, C
Stern, MC
Jarai, Z-K
Govindasami, K
Chokkalingam, AP
Hsing, AW
Goodman, PJ
Hoffmann, T
Drake, BF
Hu, JJ
Clark, PE
Van Den Eeden, SK
Blanchet, P
Fowke, JH
Casey, G
Hennis, AJM
Han, Y
Lubwama, A
Thompson, IM
Leach, R
Easton, DF
Schumacher, F
Van den Berg, DJ
Gundell, SM
Stram, A
Wan, P
Xia, L
Pooler, LC
Mohler, JL
Fontham, ETH
Smith, GJ
Taylor, JA
Srivastava, S
Eeles, RA
Carpten, J
Kibel, AS
Multigner, L
Parent, M-E
Menegaux, F
Cancel-Tassin, G
Klein, EA
Brureau, L
Stram, DO
Watya, S
Chanock, SJ
Witte, JS
Blot, WJ
Henderson, BE
Haiman, CA
PRACTICAL/ELLIPSE Consortium,
Wang, K
Sheng, X
Bensen, JT
Hazelett, DJ
Cook, MB
Ingles, SA
Kittles, RA
Strom, SS
Rybicki, BA
Nemesure, B
Isaacs, WB
Stanford, JL
Zheng, W
Sanderson, M
John, EM
Park, JY
Xu, J
Stevens, VL
Berndt, SI
Huff, CD
Wang, Z
Yeboah, ED
Tettey, Y
Biritwum, RB
Adjei, AA
Tay, E
Truelove, A
Niwa, S
Sellers, TA
Yamoah, K
Murphy, AB
Crawford, DC
Gapstur, SM
Bush, WS
Aldrich, MC
Cussenot, O
Petrovics, G
Cullen, J
Neslund-Dudas, C
Stern, MC
Jarai, Z-K
Govindasami, K
Chokkalingam, AP
Hsing, AW
Goodman, PJ
Hoffmann, T
Drake, BF
Hu, JJ
Clark, PE
Van Den Eeden, SK
Blanchet, P
Fowke, JH
Casey, G
Hennis, AJM
Han, Y
Lubwama, A
Thompson, IM
Leach, R
Easton, DF
Schumacher, F
Van den Berg, DJ
Gundell, SM
Stram, A
Wan, P
Xia, L
Pooler, LC
Mohler, JL
Fontham, ETH
Smith, GJ
Taylor, JA
Srivastava, S
Eeles, RA
Carpten, J
Kibel, AS
Multigner, L
Parent, M-E
Menegaux, F
Cancel-Tassin, G
Klein, EA
Brureau, L
Stram, DO
Watya, S
Chanock, SJ
Witte, JS
Blot, WJ
Henderson, BE
Haiman, CA
PRACTICAL/ELLIPSE Consortium,
Document Type
Journal Article
Date
2017-08-01
Date Accepted
2017-04-04
Abstract
Prostate cancer incidence is 1.6-fold higher in African Americans than in other populations. The risk factors that drive this disparity are unknown and potentially consist of social, environmental, and genetic influences. To investigate the genetic basis of prostate cancer in men of African ancestry, we performed a genome-wide association meta-analysis using two-sided statistical tests in 10 202 case subjects and 10 810 control subjects. We identified novel signals on chromosomes 13q34 and 22q12, with the risk-associated alleles found only in men of African ancestry (13q34: rs75823044, risk allele frequency = 2.2%, odds ratio [OR] = 1.55, 95% confidence interval [CI] = 1.37 to 1.76, P = 6.10 × 10-12; 22q12.1: rs78554043, risk allele frequency = 1.5%, OR = 1.62, 95% CI = 1.39 to 1.89, P = 7.50 × 10-10). At 13q34, the signal is located 5' of the gene IRS2 and 3' of a long noncoding RNA, while at 22q12 the candidate functional allele is a missense variant in the CHEK2 gene. These findings provide further support for the role of ancestry-specific germline variation in contributing to population differences in prostate cancer risk.
Citation
Journal of the National Cancer Institute, 2017, 109 (8)
Source Title
Publisher
OXFORD UNIV PRESS INC
ISSN
0027-8874
eISSN
1460-2105
Research Team
Oncogenetics