Cardiovascular disease risk among long-term testicular cancer survivors following contemporary cisplatin-based chemotherapy.
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Embargo End Date
2027-01-26
ICR Authors
Authors
Kerns, SL
Dinh, PC
Monahan, PO
Fung, C
Sesso, HD
Feldman, DR
Hamilton, RJ
Pierazio, P
Huddart, R
Kollmannsberger, C
Martin, NE
Einhorn, LH
Travis, LB
Dinh, PC
Monahan, PO
Fung, C
Sesso, HD
Feldman, DR
Hamilton, RJ
Pierazio, P
Huddart, R
Kollmannsberger, C
Martin, NE
Einhorn, LH
Travis, LB
Document Type
Journal Article
Date
2026-02-12
Date Accepted
2026-01-26
Abstract
Testicular cancer survivors (TCS) experience excess cardiovascular disease (CVD) incidence and mortality. To address the urgent need for new risk prediction tools, we evaluated the AHA's 2024 PREVENT-equation among 1,759 TC survivors (TCS; median baseline age = 37 years). Baseline median 10- and 30-year CVD risks were 1.3% and 9.1%. Among evaluated survivors with follow-up (N = 737; median age = 45), each 5% increase in 10-year PREVENT risk conferred 2.94-fold odds (95%CI = 1.99-4.35, P < .001) of incident CVD. Those with 10-year PREVENT absolute risk defined as intermediate-high (≥7.5% per AHA) had 12.11-fold higher odds (P < .001). Associations were strongest after four cycles of etoposide/cisplatin (EPX4) (OR = 4.93, P < .001), possibly driven by lower eGFR and slightly older age (P < .001 each), and among TCS without vigorous baseline physical-activity (OR = 4.25, P < .001). EPX4 patients were among those less engaged in activity (P = .005). PREVENT equations, utilizing routine measures, can identify high-risk TCS, highlighting physical-activity as a key modifiable factor for early intervention.
Citation
Journal of the National Cancer Institute, 2026, pp. djag035 -
Source Title
Journal of the National Cancer Institute
Publisher
Oxford University Press (OUP)
ISSN
0027-8874
eISSN
1460-2105
Collections
Research Team
Clinic Acad RT Huddart