Risk of thyroid disorders in adult and childhood Hodgkin lymphoma survivors 40 years after treatment.
Loading...
Embargo End Date
ICR Authors
Authors
Macklin-Doherty, A
Jones, M
Coulson, P
Bruce, C
Chau, I
Alexander, E
Iyengar, S
Taj, M
Cunningham, D
Swerdlow, A
Jones, M
Coulson, P
Bruce, C
Chau, I
Alexander, E
Iyengar, S
Taj, M
Cunningham, D
Swerdlow, A
Document Type
Journal Article
Date
2022-02-23
Date Accepted
2021-10-24
Abstract
Thyroid abnormalities are well reported following childhood treatment for Hodgkin Lymphoma (HL). Limited information exists for adult patients and after modern treatments. We analyzed risks of thyroid disorders in 237 female participants treated at the Royal Marsden Hospital 1970-2015. Multivariable analyses of risk according to treatment and time-related factors, survival analyses, and Cox regression modeling were undertaken. Overall, 33.8% of patients reported thyroid disorders (hypothyroidism 30.0% and thyroid nodules 6.8%). Cumulative prevalence was 42.9% by 40 years follow-up. Risks were greatest after supradiaphragmatic radiotherapy (RR = 5.0, p < 0.001), and increasing dose (RR = 1.03/Gy, p < 0.001). There was no association with a chemotherapy agent. Risks of thyroid disease were as raised following adult as childhood treatment. There was no trend in risk by decade of supradiaphragmatic radiotherapy treatment. Risks of thyroid disease after supradiaphragmatic radiotherapy are as great after adult as childhood treatment and persist after more recent treatment periods.
Citation
Leukemia & lymphoma, 2021, pp. 1 - 11
Source Title
Publisher
TAYLOR & FRANCIS LTD
ISSN
1042-8194
eISSN
1029-2403
1029-2403
1029-2403
Research Team
Medicine (RMH Smith Cunningham)
Aetiological Epidemiology
Aetiological Epidemiology