A risk-based approach to identifying oligometastatic disease on imaging.

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Embargo End Date

Authors

deSouza, NM
Tempany, CM

Document Type

Journal Article

Date

2019-02-01

Date Accepted

2018-07-31

Abstract

Recognition of <3 metastases in <2 organs, particularly in cancers with a known predisposition to oligometastatic disease (OMD) (colorectal, prostate, renal, sarcoma and lung), offers the opportunity to focally treat the lesions identified and confers a survival advantage. The reliability with which OMD is identified depends on the sensitivity of the imaging technique used for detection and may be predicted from phenotypic and genetic factors of the primary tumour, which determine metastatic risk. Whole-body or organ-specific imaging to identify oligometastases requires optimization to achieve maximal sensitivity. Metastatic lesions at multiple locations may require a variety of imaging modalities for best visualisation because the optimal image contrast is determined by tumour biology. Newer imaging techniques used for this purpose require validation. Additionally, rationalisation of imaging strategies is needed, particularly with regard to timing of imaging and follow-up studies. This article reviews the current evidence for the use of imaging for recognising OMD and proposes a risk-based roadmap for identifying patients with true OMD, or at risk of metastatic disease likely to be OM.

Citation

International journal of cancer, 2019, 144 (3), pp. 422 - 430

Source Title

Publisher

WILEY

ISSN

0020-7136

eISSN

1097-0215

Research Team

Magnetic Resonance

Notes