Assessment of the contribution of the IHC4+C score to decision making in clinical practice in early breast cancer.
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Embargo End Date
ICR Authors
Authors
Barton, S
Zabaglo, L
A'Hern, R
Turner, N
Ferguson, T
O'Neill, S
Hills, M
Smith, I
Dowsett, M
Zabaglo, L
A'Hern, R
Turner, N
Ferguson, T
O'Neill, S
Hills, M
Smith, I
Dowsett, M
Document Type
Journal Article
Date
2012-05-22
Date Accepted
Abstract
BACKGROUND: The immunohistochemical (IHC) 4+C score is a cost-effective prognostic tool that uses clinicopathologic factors and four standard IHC assays: oestrogen receptor (ER), PR, HER2 and Ki67. We assessed its utility in personalising breast cancer treatment in a clinical practice setting, through comparison with Adjuvant! Online (AoL) and the Nottingham Prognostic Index (NPI). METHODS: We prospectively gathered clinicopathologic data for postmenopausal patients with hormone receptor-positive, HER2-negative, N0-3 resected early breast cancer treated consecutively at our institution. We retrospectively calculated and compared prognostic scores. The primary endpoint was the proportion of patients reclassified from AoL-defined intermediate-risk by application of the IHC4+C score. RESULTS: The median age of the 101 patients included in the analysis was 63. In all, 15 of the 26 patients classified as intermediate-risk by AoL were reallocated to a low-risk group by application of the IHC4+C score and no patient was reclassified as high-risk group. Of the 59 patients classified as intermediate-risk group by the NPI, 24 were reallocated to a low-risk group and 13 to a high-risk group. CONCLUSION: IHC4+C reclassifies more than half of the patients stratified as being in intermediate-risk group by the AoL and NPI. The use of IHC4+C may substantially improve decision-making on adjuvant chemotherapy.
Citation
British journal of cancer, 2012, 106 (11), pp. 1760 - 1765
Source Title
Publisher
SPRINGERNATURE
ISSN
0007-0920
eISSN
1532-1827
Research Team
Molecular Oncology
Clinical Trials & Statistics Unit
Medicine (RMH Smith Cunningham)
Endocrinology
Clinical Trials & Statistics Unit
Medicine (RMH Smith Cunningham)
Endocrinology