Measuring Clonal Evolution in Cancer with Genomics.
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Embargo End Date
ICR Authors
Authors
Williams, MJ
Sottoriva, A
Graham, TA
Sottoriva, A
Graham, TA
Document Type
Journal Article
Date
2019-08-31
Date Accepted
2019-05-06
Abstract
Cancers originate from somatic cells in the human body that have accumulated genetic alterations. These mutations modify the phenotype of the cells, allowing them to escape the homeostatic regulation that maintains normal cell number. Viewed through the lens of evolutionary biology, the transformation of normal cells into malignant cells is evolution in action. Evolution continues throughout cancer growth, progression, treatment resistance, and disease relapse, driven by adaptation to changes in the cancer's environment, and intratumor heterogeneity is an inevitable consequence of this evolutionary process. Genomics provides a powerful means to characterize tumor evolution, enabling quantitative measurement of evolving clones across space and time. In this review, we discuss concepts and approaches to quantify and measure this evolutionary process in cancer using genomics.
Citation
Annual review of genomics and human genetics, 2019, 20 pp. 309 - 329
Source Title
Publisher
ANNUAL REVIEWS
ISSN
1527-8204
eISSN
1545-293X