Incidental finding of leukaemia in circulating tumour DNA- the importance of a molecular tumour board.
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Embargo End Date
ICR Authors
Authors
Mencel, J
Rayarel, N
Proszek, P
Carter, P
Feber, A
Popat, S
McVeigh, TP
George, A
Dunlop, A
Hardy, K
Chau, I
Cunningham, D
Kohoutova, D
Lee, R
Iyengar, S
Starling, N
Rayarel, N
Proszek, P
Carter, P
Feber, A
Popat, S
McVeigh, TP
George, A
Dunlop, A
Hardy, K
Chau, I
Cunningham, D
Kohoutova, D
Lee, R
Iyengar, S
Starling, N
Document Type
Journal Article
Date
2024-02-13
Date Accepted
2023-12-22
Abstract
As the use of liquid biopsies are increasing across multiple indications in cancer medicine, the detection of incidental findings on circulating tumour DNA is of increasing importance. We report the finding of leukaemia detected in a patient who underwent plasma-based circulating tumour DNA next generation screening as part of a screening liquid biopsy study. A BRAF V600E mutation detected was deemed pathogenic following discussion at a molecular tumour board, and recommendation of further investigations led to the diagnosis of an occult haematological malignancy. We report the importance of molecular tumour board discussion and recommendations in the identification of incidental, pathogenic findings on circulating tumour DNA.
Citation
BJC Reports, 2024, 2 (1), pp. 12 -
Source Title
BJC Reports
Publisher
SPRINGERNATURE
ISSN
2731-9377
eISSN
2731-9377
Collections
Research Team
Cancer Genetics Edu&Qual
Medicine (RMH)