Development and Characterisation of Clinically Relevant Tissue Mimics for an Ultrasound Drug Delivery Phantom
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Embargo End Date
ICR Authors
Authors
Braunstein, L
Document Type
Thesis or Dissertation
Date
2024-09-19
Date Accepted
Abstract
Ultrasound (US) can be used for therapeutic applications, by exploiting the thermal and mechanical
effects induced in tissue. Knowledge of the acoustic, thermal and cavitation properties of tissue and
tissue mimicking materials (TMMs), which display the properties of different soft tissues, is essential
for experimental evaluation of therapeutic US. Furthermore, the use of TMMs to create a US drug
delivery phantom, will help in understanding the modalities and physical effects of cavitation.
The first two chapters of this thesis will review the current knowledge about therapeutic US,
characterisation techniques for relevant acoustic and thermal properties of tissues, and the need for
TMMs and phantoms, and potential candidates for these. The thesis will then focus on TMM
development, and the methodologies used here for acoustic, thermal and cavitation property
characterisation of tissue and TMMs, moving on to the results and their discussion. The sixth
chapter will focus on the design, development and set up of a US drug delivery phantom. The final
chapter will summarise the overall work and give conclusions, and suggest potential future work
Citation
2024
DOI
Source Title
Publisher
Institute of Cancer Research (University Of London)
ISSN
eISSN
Collections
Research Team
Therapeutic Ultrasound