The diagnostic value of 18F-FDG-PET/CT and MRI in suspected vertebral osteomyelitis - a prospective study.
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ICR Authors
Authors
Kouijzer, IJE
Scheper, H
de Rooy, JWJ
Bloem, JL
Janssen, MJR
van den Hoven, L
Hosman, AJF
Visser, LG
Oyen, WJG
Bleeker-Rovers, CP
de Geus-Oei, L-F
Scheper, H
de Rooy, JWJ
Bloem, JL
Janssen, MJR
van den Hoven, L
Hosman, AJF
Visser, LG
Oyen, WJG
Bleeker-Rovers, CP
de Geus-Oei, L-F
Document Type
Journal Article
Date
2018-05
Date Accepted
2017-12-10
Abstract
PURPOSE:The aim of this study was to determine the diagnostic value of 18F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT) and magnetic resonance imaging (MRI) in diagnosing vertebral osteomyelitis. METHODS:From November 2015 until December 2016, 32 patients with suspected vertebral osteomyelitis were prospectively included. All patients underwent both 18F-FDG-PET/CT and MRI within 48 h. All images were independently reevaluated by two radiologists and two nuclear medicine physicians who were blinded to each others' image interpretation. 18F-FDG-PET/CT and MRI were compared to the clinical diagnosis according to international guidelines. RESULTS:For 18F-FDG-PET/CT, sensitivity, specificity, PPV, and NPV in diagnosing vertebral osteomyelitis were 100%, 83.3%, 90.9%, and 100%, respectively. For MRI, sensitivity, specificity, PPV, and NPV were 100%, 91.7%, 95.2%, and 100%, respectively. MRI detected more epidural/spinal abscesses. An important advantage of 18F-FDG-PET/CT is the detection of metastatic infection (16 patients, 50.0%). CONCLUSION:18F-FDG-PET/CT and MRI are both necessary techniques in diagnosing vertebral osteomyelitis. An important advantage of 18F-FDG-PET/CT is the visualization of metastatic infection, especially in patients with bacteremia. MRI is more sensitive in detection of small epidural abscesses.
Citation
European journal of nuclear medicine and molecular imaging, 2018, 45 (5), pp. 798 - 805
Source Title
Publisher
ISSN
1619-7070
eISSN
1619-7089
Collections
Research Team
Translational Molecular Imaging