The association between smoking cessation before and after diagnosis and non-muscle-invasive bladder cancer recurrence: a prospective cohort study.
Loading...
Embargo End Date
ICR Authors
Authors
van Osch, FHM
Jochems, SHJ
Reulen, RC
Pirrie, SJ
Nekeman, D
Wesselius, A
James, ND
Wallace, DMA
Cheng, KK
van Schooten, FJ
Bryan, RT
Zeegers, MP
Jochems, SHJ
Reulen, RC
Pirrie, SJ
Nekeman, D
Wesselius, A
James, ND
Wallace, DMA
Cheng, KK
van Schooten, FJ
Bryan, RT
Zeegers, MP
Document Type
Journal Article
Date
2018-07-01
Date Accepted
Abstract
BACKGROUND: Smoking is a major risk factor for bladder cancer, but the relationship between smoking cessation after initial treatment and bladder cancer recurrence has been investigated less frequently and not prospectively yet. METHODS: 722 non-muscle-invasive bladder cancer (NMIBC) patients (pTa, pT1, and CIS) from the prospective Bladder Cancer Prognosis Programme (BCPP) cohort, selected in the UK between 2005 and 2011, provided complete data on smoking behavior before and up to 5 years after diagnosis. The impact of smoking behavior on NMIBC recurrence was explored by multivariable Cox regression models investigating time-to-first NMIBC recurrence. RESULTS: Over a median follow-up period of 4.21 years, 403 pathologically confirmed NMIBC recurrences occurred in 210 patients. Only 25 current smokers at diagnosis quit smoking (14%) during follow-up and smoking cessation after diagnosis did not decrease risk of recurrence compared to continuing smokers (p = 0.352). CONCLUSIONS: Although quitting smoking after diagnosis might reduce the risk of recurrence based on retrospective evidence, this is not confirmed in this prospective study because the number of NMIBC patients quitting smoking before their first recurrence was too low. Nevertheless, this indicates an important role for urologists and other health care professionals in promoting smoking cessation in NMIBC.
Citation
Cancer Causes & Control, 2018, 29 (7), pp. 675 - 683
Source Title
Publisher
SPRINGER
ISSN
0957-5243
eISSN
1573-7225
Collections
Research Team
Prostate and Bladder Cancer Research