Gene Regulatory Networks and Transcriptional Mechanisms that Control Myogenesis
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Embargo End Date
ICR Authors
Authors
Buckingham, M
Rigby, PWJ
Rigby, PWJ
Document Type
Journal Article
Date
2014-02-10
Date Accepted
Abstract
We discuss the upstream regulators of myogenesis that lead to the activation of myogenic determination genes and subsequent differentiation, focusing on the mouse model. Key upstream genes, such as Pax3 and Pax7, Six1 and Six4, or Pitx2, participate in gene regulatory networks at different sites of skeletal muscle formation. MicroRNAs also intervene, with emerging evidence for the role of other noncoding RNAs. Myogenic determination and subsequent differentiation depend on members of the MyoD family. We discuss new insights into mechanisms underlying the transcriptional activity of these factors.
Citation
DEVELOPMENTAL CELL, 2014, 28 pp. 225 - 238
Source Title
Publisher
CELL PRESS
ISSN
1534-5807
eISSN
1878-1551
Collections
Research Team
Molecular Embryology