Joint ABS-UKCGG-CanGene-CanVar consensus regarding the use of CanRisk in clinical practice.
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Embargo End Date
ICR Authors
Authors
Tsoulaki, O
Tischkowitz, M
Antoniou, AC
Musgrave, H
Rea, G
Gandhi, A
Cox, K
Irvine, T
Holcombe, S
Eccles, D
Turnbull, C
Cutress, R
Meeting Attendees,
Archer, S
Hanson, H
Tischkowitz, M
Antoniou, AC
Musgrave, H
Rea, G
Gandhi, A
Cox, K
Irvine, T
Holcombe, S
Eccles, D
Turnbull, C
Cutress, R
Meeting Attendees,
Archer, S
Hanson, H
Document Type
Journal Article
Date
2024-06-29
Date Accepted
2024-05-21
Abstract
BACKGROUND: The CanRisk tool, which operationalises the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) is used by Clinical Geneticists, Genetic Counsellors, Breast Oncologists, Surgeons and Family History Nurses for breast cancer risk assessments both nationally and internationally. There are currently no guidelines with respect to the day-to-day clinical application of CanRisk and differing inputs to the model can result in different recommendations for practice. METHODS: To address this gap, the UK Cancer Genetics Group in collaboration with the Association of Breast Surgery and the CanGene-CanVar programme held a workshop on 16th of May 2023, with the aim of establishing best practice guidelines. RESULTS: Using a pre-workshop survey followed by structured discussion and in-meeting polling, we achieved consensus for UK best practice in use of CanRisk in making recommendations for breast cancer surveillance, eligibility for genetic testing and the input of available information to undertake an individualised risk assessment. CONCLUSIONS: Whilst consensus recommendations were achieved, the meeting highlighted some of the barriers limiting the use of CanRisk in clinical practice and identified areas that require further work and collaboration with relevant national bodies and policy makers to incorporate wider use of CanRisk into routine breast cancer risk assessments.
Citation
British Journal of Cancer, 2024, 130 (12), pp. 2027 - 2036
Source Title
British Journal of Cancer
Publisher
SPRINGERNATURE
ISSN
0007-0920
eISSN
1532-1827
1532-1827
1532-1827
Collections
Research Team
Translational Genetics