Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C).
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Embargo End Date
ICR Authors
Authors
Alfieri, C
Zhang, S
Barford, D
Zhang, S
Barford, D
Document Type
Journal Article
Date
2017-11-01
Date Accepted
2017-10-10
Abstract
The anaphase promoting complex or cyclosome (APC/C) is a large multi-subunit E3 ubiquitin ligase that orchestrates cell cycle progression by mediating the degradation of important cell cycle regulators. During the two decades since its discovery, much has been learnt concerning its role in recognizing and ubiquitinating specific proteins in a cell-cycle-dependent manner, the mechanisms governing substrate specificity, the catalytic process of assembling polyubiquitin chains on its target proteins, and its regulation by phosphorylation and the spindle assembly checkpoint. The past few years have witnessed significant progress in understanding the quantitative mechanisms underlying these varied APC/C functions. This review integrates the overall functions and properties of the APC/C with mechanistic insights gained from recent cryo-electron microscopy (cryo-EM) studies of reconstituted human APC/C complexes.
Citation
Open biology, 2017, 7 (11)
Source Title
Publisher
ROYAL SOC
ISSN
2046-2441
eISSN
2046-2441
Collections
Research Team
Molecular mechanisms of cell cycle regulation