How Low Can You Go? The Radiobiology of Hypofractionation.
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Embargo End Date
ICR Authors
Authors
Brand, DH
Kirby, AM
Yarnold, JR
Somaiah, N
Kirby, AM
Yarnold, JR
Somaiah, N
Document Type
Journal Article
Date
2022-05-01
Date Accepted
2022-02-11
Abstract
Hypofractionated radical radiotherapy is now an accepted standard of care for tumour sites such as prostate and breast cancer. Much research effort is being directed towards more profoundly hypofractionated (ultrahypofractionated) schedules, with some reaching UK standard of care (e.g. adjuvant breast). Hypofractionation exerts varying influences on each of the major clinical end points of radiotherapy studies: acute toxicity, late toxicity and local control. This review will discuss these effects from the viewpoint of the traditional 5 Rs of radiobiology, before considering non-canonical radiobiological effects that may be relevant to ultrahypofractionated radiotherapy. The principles outlined here may assist the reader in their interpretation of the wealth of clinical data presented in the tumour site-specific articles in this special issue.
Citation
Clinical oncology (Royal College of Radiologists (Great Britain)), 2022, 34 (5), pp. 280 - 287
Source Title
Publisher
ELSEVIER SCIENCE LONDON
ISSN
0936-6555
eISSN
1433-2981
1433-2981
1433-2981
Collections
Research Team
Breast Cancer Radiotherapy
Stereotactic and Precision Body Radiotherapy
Translational Breast Radiobiology
Stereotactic and Precision Body Radiotherapy
Translational Breast Radiobiology