ELM-the eukaryotic linear motif resource in 2020.
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Embargo End Date
ICR Authors
Authors
Kumar, M
Gouw, M
Michael, S
Sámano-Sánchez, H
Pancsa, R
Glavina, J
Diakogianni, A
Valverde, JA
Bukirova, D
Čalyševa, J
Palopoli, N
Davey, NE
Chemes, LB
Gibson, TJ
Gouw, M
Michael, S
Sámano-Sánchez, H
Pancsa, R
Glavina, J
Diakogianni, A
Valverde, JA
Bukirova, D
Čalyševa, J
Palopoli, N
Davey, NE
Chemes, LB
Gibson, TJ
Document Type
Journal Article
Date
2020-01-08
Date Accepted
2019-10-23
Abstract
The eukaryotic linear motif (ELM) resource is a repository of manually curated experimentally validated short linear motifs (SLiMs). Since the initial release almost 20 years ago, ELM has become an indispensable resource for the molecular biology community for investigating functional regions in many proteins. In this update, we have added 21 novel motif classes, made major revisions to 12 motif classes and added >400 new instances mostly focused on DNA damage, the cytoskeleton, SH2-binding phosphotyrosine motifs and motif mimicry by pathogenic bacterial effector proteins. The current release of the ELM database contains 289 motif classes and 3523 individual protein motif instances manually curated from 3467 scientific publications. ELM is available at: http://elm.eu.org.
Citation
Nucleic acids research, 2020, 48 (D1), pp. D296 - D306
Source Title
Publisher
OXFORD UNIV PRESS
ISSN
0305-1048
eISSN
1362-4962