Rare Aggressive Behavior of MDM2-Amplified Retroperitoneal Dedifferentiated Liposarcoma, with Brain, Lung and Subcutaneous Metastases.
Loading...
Embargo End Date
ICR Authors
Authors
Ben Salha, I
Zaidi, S
Noujaim, J
Miah, AB
Fisher, C
Jones, RL
Thway, K
Zaidi, S
Noujaim, J
Miah, AB
Fisher, C
Jones, RL
Thway, K
Document Type
Journal Article
Date
2016-09-05
Date Accepted
2016-02-25
Abstract
Dedifferentiated liposarcoma (DDL) is a histologically pleomorphic sarcoma, traditionally defined as well-differentiated liposarcoma with abrupt transition to high grade, non-lipogenic sarcoma. It can occur as part of recurrent well-differentiated liposarcoma, or may arise de novo. DDL most frequently occurs within the retroperitoneum, and while it is prone to local recurrence, it usually has a lower rate of metastasis than other pleomorphic sarcomas. We describe a case of retroperitoneal dedifferentiated liposarcoma in a 63-year-old male, who showed MDM2 amplification with fluorescence in situ hybridization, which displayed unusually aggressive behavior, with brain, lung and subcutaneous soft tissue metastases. As previous reports of metastatic liposarcoma have largely grouped DDL in with other (genetically and clinically distinct) liposarcoma subtypes, we highlight and discuss the rare occurrence of brain metastasis in MDM2-amplified retroperitoneal liposarcoma.
Citation
Rare tumors, 2016, 8 (3), pp. 6282 - ?
Source Title
Publisher
SAGE PUBLICATIONS LTD
ISSN
2036-3605
eISSN
2036-3613
Research Team
Sarcoma Clinical Trials (R Jones)
Targeted Therapy
Targeted Therapy