The Heterocellular Emergence of Colorectal Cancer.
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Embargo End Date
ICR Authors
Authors
Tape, CJ
Document Type
Journal Article
Date
2017-02
Date Accepted
Abstract
Tissues contain multiple different cell types and can be considered to be heterocellular systems. Signaling between different cells allows tissues to achieve phenotypes that no cell type can achieve in isolation. Such emergent tissue-level phenotypes can be said to 'supervene upon' heterocellular signaling. It is proposed here that cancer is also an emergent phenotype that supervenes upon heterocellular signaling. Using colorectal cancer (CRC) as an example, I review how heterotypic cells differentially communicate to support emergent malignancy. Studying tumors as integrated heterocellular systems - rather than as solitary expansions of mutated cells - may reveal novel ways to treat cancer.
Citation
Trends in cancer, 2017, 3 (2), pp. 79 - 88
Source Title
Publisher
ISSN
2405-8033
eISSN
2405-8025
Collections
Research Team
Oncogene